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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
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[MORPHOGENETIC PROTEINS--FIBROBLAST GROWTH FACTOR AND KLOTHO, IN THE SERA OF PATIENTS WITH CHRONIC RENAL DISEASE]
Klinicheskaia Meditsina
|May 7, 2016
Summary
Fibroblast growth factor-23 (FGF-23) and Klotho protein levels decrease with chronic renal disease (CRD) progression. These proteins are valuable early markers for cardiovascular risk, including cardiac calcification and hypertrophy, in CRD patients.
Area of Science:
- Nephrology
- Cardiology
- Endocrinology
Background:
- Chronic renal disease (CRD) is associated with increased cardiovascular risk.
- Morphogenetic proteins, fibroblast growth factor-23 (FGF-23) and Klotho, play roles in mineral metabolism.
- The utility of FGF-23 and Klotho as early cardiovascular risk markers in CRD requires further investigation.
Purpose of the Study:
- To evaluate fibroblast growth factor-23 (FGF-23) and Klotho as serum markers of cardiovascular risk in patients with chronic renal disease (CRD).
- To assess the relationship between FGF-23 and Klotho levels and cardiovascular complications such as cardiac calcification and left ventricular hypertrophy.
Main Methods:
- Serum FGF-23 and Klotho levels were measured using ELISA in 130 CRD patients and 30 healthy controls.
- Cardiovascular parameters including blood pressure, pulse wave velocity, ECG, EchoCG, and abdominal aorta X-ray were assessed.
- Statistical analyses, including correlation, multiple regression, and ROC analysis, were employed to determine associations.
Main Results:
- FGF-23 and Klotho levels decreased with declining glomerular filtration rate in CRD patients.
- Lower Klotho levels correlated with increased cardiac calcification, while higher FGF-23 correlated with myocardial remodeling.
- Elevated FGF-23 and Klotho levels were predictive of left ventricular hypertrophy and increased mortality risk in hemodialysis patients.
Conclusions:
- Fibroblast growth factor-23 (FGF-23) and Klotho are important not only for mineral metabolism but also for cardiovascular complications in CRD.
- These proteins serve as valuable early indicators of cardiovascular risk, including calcification and remodeling, in patients with chronic renal disease.
- FGF-23 and Klotho demonstrate potential as biomarkers for predicting cardiovascular events and mortality in CRD populations.
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