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Tumor suppressive actions of the nuclear receptor corepressor 1

Olaia Martínez-Iglesias1, Elvira Alonso-Merino1, Ana Aranda1

  • 1Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Spain.

Pharmacological Research
|May 7, 2016
PubMed

Insights

Nuclear Receptor Corepressor 1 (NCoR) acts as a tumor suppressor, inhibiting cancer invasion and metastasis. Its loss can propagate, driving tumor progression and highlighting NCoR as a potential cancer therapy target.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Nuclear Receptor Corepressor 1 (NCoR) is a key transcriptional regulator.
  • Inactivating mutations/deletions in the NCoR gene are found in human tumors.
  • NCoR exhibits significant tumor suppressor activity.

Purpose of the Study:

  • To investigate the role of NCoR in tumor suppression and metastasis.
  • To explore the mechanisms of NCoR deficiency in cancer progression.
  • To evaluate NCoR as a potential therapeutic target.

Main Methods:

  • Analysis of NCoR gene mutations in human tumors.
  • Assessment of NCoR's effect on invasion, metastasis, and tumor growth in mouse models.
  • Investigation of NCoR gene transcription regulation by thyroid hormone receptor TRβ.

Main Results:

  • NCoR deficiency inhibits metastasis and tumor growth.
  • NCoR loss leads to transcriptional repression of poor-prognosis genes.
  • NCoR deficiency can be propagated, contributing to tumor progression.
  • Thyroid hormone receptor TRβ upregulates NCoR, mediating its anti-metastatic effects.

Conclusions:

  • NCoR is a crucial tumor suppressor with potent anti-metastatic activity.
  • NCoR deficiency plays a role in cancer progression, independent of gene mutations.
  • Targeting NCoR represents a promising strategy for cancer therapy, particularly for preventing metastasis.
Keywords:
CancerGene transcriptionMetastasisNuclear receptor corepressor 1

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