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The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability

Pablo Rozas1, Leslie Bargsted1, Francisca Martínez1

  • 1Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago 8380453, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Center for Molecular Studies of the Cell, University of Chile, Santiago 8380453, Chile; Center for Geroscience, Brain Health and Metabolism, University of Chile, Santiago, Chile.

Neuroscience Letters
|May 7, 2016
PubMed
Summary

Amyotrophic lateral sclerosis (ALS) involves motoneuron loss driven by endoplasmic reticulum (ER) stress. Targeting the unfolded protein response (UPR) may offer a therapeutic strategy for this neurodegenerative disease.

Keywords:
ALSChaperonesER stressProteostasisSelective vulnerability

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