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Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
Published on: August 29, 2016
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Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens
Markus von Schaewen1, Gabriela Hrebikova1, Alexander Ploss2
1Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA.
Methods in Molecular Biology (Clifton, N.J.)
|May 7, 2016
Abstract:
Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.
Keywords:
DMPKHepatitis B virusHepatitis C virusHepatitis delta virusHuman liver chimeric miceHumanized miceMalariaViral hepatitis
