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Updated: Mar 21, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Medicinal Chemistry Perspective of Fused Isoxazole Derivatives
Mahesh A Barmade, Prashant R Murumkar, Mayank Kumar Sharma
1Faculty of Pharmacy, Kalabhavan, The Maharaja Sayajirao University of Baroda, Vadodara- 390 001, Gujarat, India. mryadav11@yahoo.co.in.
Abstract:
Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives.
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