Related Experiment Video
Updated: Mar 21, 2026

10:41
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
10.9K
The shocking consequences of hybrid epigenomes
William T Jordan1, Robert J Schmitz2
1Department of Genetics, University of Georgia, 120 East Green Street, Athens, GA, 30602, USA.
Genome Biology
|May 7, 2016
Summary
Spontaneous epialleles arise from novel mechanisms. A new study reveals that the formation of epihybrids can generate new epialleles, offering insights into epigenetic variation.
Area of Science:
- Epigenetics and molecular biology.
Background:
- The mechanisms underlying spontaneous epiallele formation remain largely unknown.
- Epialleles represent epigenetic alleles that influence gene expression without altering DNA sequence.
Purpose of the Study:
- To investigate the role of epihybrid formation in the generation of novel epialleles.
- To elucidate the processes contributing to epigenetic variation.
Main Methods:
- Analysis of epigenetic inheritance patterns.
- Molecular techniques to identify and characterize epialleles.
Main Results:
- The study demonstrates that the formation of epihybrids is a viable pathway for generating new epialleles.
- Evidence suggests that recombination events within epihybrids can lead to novel epigenetic states.
Conclusions:
- Epihybrid formation is a significant contributor to the emergence of spontaneous epialleles.
- Understanding these mechanisms is crucial for comprehending epigenetic diversity and evolution.
Related Concept Videos
Heterochromatin
19.0K
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
19.0K
Heterochromatin
4.9K
4.9K
Epigenetic Regulation
4.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
4.1K
Epigenetic Regulation
26.2K
26.2K
Epigenetic Regulation
34.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.2K
Hybrid Zones
22.5K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
22.5K

