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Parkinsonism as a side effect of infliximab

Jakob Nørgaard Henriksen1, Bengt Oluf Mikael Eriksson2

  • 1Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark.

BMJ Case Reports
|May 7, 2016
PubMed

Insights

A man with Crohn's disease developed parkinsonism after infliximab treatment. Symptoms improved after discontinuing the drug, suggesting a potential link between infliximab and parkinsonism.

Area of Science:

  • Gastroenterology
  • Neurology
  • Immunology

Background:

  • Crohn's disease is a chronic inflammatory bowel disease.
  • Infliximab is a biologic therapy used for Crohn's disease.
  • Parkinsonism is a neurological disorder characterized by movement abnormalities.

Observation:

  • A 64-year-old male with a 30-year history of Crohn's disease was treated with infliximab.
  • Within 3 days of the first infliximab dose, the patient developed a resting tremor.
  • Parkinsonism symptoms progressed over 4 months, affecting both legs and hands.

Findings:

  • Infliximab treatment was withdrawn after 4 months due to lack of efficacy and symptom development.
  • The patient experienced gradual improvement in resting tremor after infliximab discontinuation.
  • This case suggests a potential association between infliximab and the development of parkinsonism.

Implications:

  • This report highlights a rare adverse effect of infliximab, potentially parkinsonism.
  • Further investigation is warranted to understand the mechanism linking infliximab to parkinsonism.
  • Clinicians should monitor for neurological side effects in patients treated with infliximab.

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