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Updated: Mar 21, 2026

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses
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The accommodative ciliary muscle function is preserved in older humans.

Juan Tabernero1, Emmanuel Chirre1, Lucia Hervella1

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Even in advanced age, the ciliary muscle remains active, suggesting presbyopia stems primarily from lens changes. This finding may lead to new treatments for age-related vision loss.

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Area of Science:

  • Ophthalmology
  • Vision Science
  • Gerontology

Background:

  • Presbyopia, the age-related loss of accommodation, affects individuals over 45-50.
  • It is attributed to lens hardening and reduced ciliary muscle function.
  • The ciliary muscle's activity in advanced presbyopia remains unclear.

Purpose of the Study:

  • To investigate ciliary muscle activity in elderly pseudophakic subjects.
  • To explore the role of the ciliary muscle in advanced presbyopia.
  • To assess the viability of new presbyopia treatment strategies.

Main Methods:

  • Developed a novel method using high-speed recording of lens wobbling.
  • Studied ciliary muscle activity in a small group of ~80-year-old pseudophakic individuals.
  • Applied binocular stimulation to assess accommodation response.

Main Results:

  • Significant ciliary muscle activity was detected in elderly subjects.
  • The muscle demonstrated a clear ability to contract during accommodation.
  • Evidence supports a lens-based theory for presbyopia development.

Conclusions:

  • The aging ciliary muscle retains contractile function.
  • This supports a purely lenticular basis for presbyopia.
  • Findings may encourage development of new presbyopia solutions targeting residual muscle force.