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Genome Sequence of the Multiantibiotic-Resistant Enterococcus faecium Strain C68 and Insights on the pLRM23

Mónica García-Solache1, Louis B Rice2

  • 1Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA monica.garciasolache@cantab.net.

Genome Announcements
|May 7, 2016
PubMed

Insights

Multiantibiotic-resistant Enterococcus faecium strains are a growing hospital concern. This study presents the genome of a specific resistant strain, C68, useful for further research into these difficult-to-treat infections.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Enterococcus faecium infections pose a significant and increasing threat in healthcare environments.
  • Vancomycin-resistant enterococci (VRE) are problematic as they colonize the gut and outcompete susceptible strains.
  • Treatment of VRE infections in vulnerable patients is challenging.

Purpose of the Study:

  • To provide a high-quality genome sequence of a multiantibiotic-resistant Enterococcus faecium strain.
  • To make the genome of strain C68 available for experimental and research purposes.

Main Methods:

  • Whole-genome sequencing of the clinical isolate Enterococcus faecium C68.
  • Genome polishing and analysis to ensure accuracy and completeness.

Main Results:

  • A polished genome sequence for the multiantibiotic-resistant Enterococcus faecium strain C68 has been generated.
  • Strain C68 is confirmed as a valuable resource for experimental studies.

Conclusions:

  • The availability of the C68 genome sequence facilitates research into multiantibiotic resistance mechanisms in Enterococcus faecium.
  • This resource aids in understanding and combating VRE infections in clinical settings.

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