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Draft Genome Sequence of Vancomycin-Susceptible, Ampicillin-Intermediate Enterococcus faecium Strain D344RRF

Mónica García-Solache1, Louis B Rice2

  • 1Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA monica.garciasolache@cantab.net.

Genome Announcements
|May 7, 2016
PubMed

Insights

We present the genome of Enterococcus faecium strain D344RRF, a valuable lab tool for studying antibiotic resistance transfer. This strain exhibits resistance to rifampicin and fusidic acid.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Enterococcus faecium is a significant cause of hospital-acquired infections.
  • High antibiotic resistance rates in E. faecium contribute to a major health burden.
  • The bacterium's ability to colonize the gastrointestinal tract facilitates its spread.

Purpose of the Study:

  • To provide the draft genome sequence of a specific Enterococcus faecium laboratory strain.
  • To characterize the antibiotic resistance profile of strain D344RRF.
  • To highlight the utility of this strain in research on antibiotic resistance mechanisms.

Main Methods:

  • Whole-genome sequencing of Enterococcus faecium strain D344RRF.
  • Bioinformatic analysis of the generated genome data.
  • Phenotypic characterization of antibiotic susceptibility.

Main Results:

  • The draft genome sequence for vancomycin-susceptible, ampicillin-intermediate E. faecium strain D344RRF was obtained.
  • Strain D344RRF displays resistance to rifampicin and fusidic acid.
  • This characterized genome provides a resource for resistance studies.

Conclusions:

  • The genome of E. faecium D344RRF is a valuable resource for investigating antibiotic resistance.
  • This strain's specific resistance profile makes it suitable for studying resistance transfer mechanisms.
  • Further research utilizing this genomic data can advance understanding of nosocomial pathogens.

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