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Soy-based renoprotection.

Nancy J McGraw1, Elaine S Krul1, Elizabeth Grunz-Borgmann1

  • 1Nancy J McGraw, Elaine S Krul, Global Nutrition, DuPont Nutrition and Health, Saint Louis, MO 63101, United States.

World Journal of Nephrology
|May 7, 2016
PubMed
Summary
This summary is machine-generated.

Soybean protein shows promise in protecting kidney health by slowing disease progression and improving markers like proteinuria. Further research is needed to fully understand its cellular mechanisms in chronic kidney disease (CKD).

Keywords:
Chronic kidney diseaseDietProteinProteinuriaSoy

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Area of Science:

  • Nephrology
  • Nutritional Science
  • Molecular Biology

Background:

  • Chronic kidney disease (CKD) is a growing global health issue with limited pharmacologic treatments.
  • Dietary interventions, particularly protein source, are crucial for managing CKD progression and symptoms.
  • Soybean protein is the most studied plant-based protein for renal health.

Purpose of the Study:

  • To review the renal protective properties of soybean protein in CKD patients.
  • To explore the impact of soy protein on CKD risk factors and molecular mechanisms.
  • To highlight the need for further research into soy's cellular targets in renal function.

Main Methods:

  • Review of clinical studies on soybean protein in CKD patients.
  • Analysis of animal model studies identifying molecular mechanisms.
  • Examination of soy's effects on risk factors like dyslipidemia, hypertension, and hyperglycemia.

Main Results:

  • Soy protein consumption slows estimated glomerular filtration rate decline and reduces proteinuria.
  • Soy intake positively impacts CKD risk factors including dyslipidemia, hypertension, and hyperglycemia.
  • Soy protein intake is linked to improved antioxidant status and reduced systemic inflammation in CKD patients.

Conclusions:

  • Soybean protein demonstrates significant renal protective effects in various CKD models.
  • Soy protein may benefit kidney function through its impact on physiological risk factors and inflammation.
  • Further investigation is required to elucidate the specific cellular and molecular targets of soy protein in renoprotection.