Stop chronic kidney disease progression: Time is approaching.

Area of Science:

• Nephrology
• Genetics
• Gastroenterology

Background:

• Chronic kidney disease (CKD) progression is a significant clinical challenge.
• Recent advancements have improved management strategies for various CKD etiologies.
• Systemic inflammation and oxidative stress are key contributors to CKD pathogenesis.

Purpose of the Study:

• To review recent discoveries in CKD management.
• To explore the role of Klotho gene expression in CKD.
• To investigate the gut's contribution to inflammation and its therapeutic potential in delaying CKD progression.

Main Methods:

• Literature review of recent advancements in CKD management.
• Analysis of the impact of inflammation on Klotho gene expression.
• Examination of gut barrier damage, intestinal alkaline phosphatase, and dietary factors.

Main Results:

• Significant progress has been made in managing diabetic kidney disease, glomerulonephritis, polycystic kidney disease, amyloidosis, and tubulointerstitial disease.
• Chronic inflammation negatively impacts anti-senescence Klotho gene expression.
• The gut microbiome and intestinal health represent a novel therapeutic target for CKD.

Conclusions:

• The progression of CKD may be significantly delayed with emerging therapeutic strategies.
• Targeting systemic inflammation, oxidative stress, and gut health holds promise for CKD treatment.
• Klotho gene therapy and modulation of gut-derived inflammation are potential future directions in CKD care.