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Diagnostic Value of Serum YKL-40 Level for Coronary Artery Disease: A Meta-Analysis

Chun-Li Song, Bin-Li, Hong-Ying Diao

    Journal of Clinical Laboratory Analysis
    |May 7, 2016
    PubMed

    Insights

    Elevated serum YKL-40 levels are a promising indicator for diagnosing coronary artery disease (CAD). This meta-analysis confirms higher YKL-40 in CAD patients, suggesting its diagnostic value.

    Area of Science:

    • Biomarkers and Diagnostics
    • Cardiovascular Research
    • Medical Research

    Background:

    • Coronary artery disease (CAD) poses a significant global health challenge.
    • Early and accurate diagnosis of CAD is crucial for effective management and improved patient outcomes.
    • Identifying reliable diagnostic markers for CAD remains an active area of research.

    Purpose of the Study:

    • To evaluate the diagnostic value of serum YKL-40 levels in patients with coronary artery disease (CAD).
    • To synthesize evidence from multiple studies to determine the association between YKL-40 and CAD.
    • To assess the potential of serum YKL-40 as an early diagnostic tool for CAD.

    Main Methods:

    • A comprehensive meta-analysis was conducted by searching multiple electronic databases, including PubMed, Web of Science, and EMBASE.
    • Eleven clinical case-control studies involving 1,175 CAD patients and 1,261 healthy controls were included.
    • Statistical analysis was performed using STATA software, calculating standard mean difference (SMD) with 95% confidence intervals (CI).

    Main Results:

    • The meta-analysis revealed significantly higher serum YKL-40 levels in CAD patients compared to healthy controls (SMD = 2.79, 95% CI = 1.73–3.85, P < 0.001).
    • Ethnicity-stratified analyses showed elevated YKL-40 in CAD patients across Chinese, Korean, and Danish populations.
    • No significant difference was observed in the Turkish population (SMD = 4.52, 95% CI = -2.87–11.91, P = 0.231).

    Conclusions:

    • Elevated serum YKL-40 levels show promise as a diagnostic biomarker for coronary artery disease (CAD).
    • This finding supports the potential utility of YKL-40 for the early identification of individuals with CAD.
    • Further research may validate YKL-40 as a routine diagnostic marker in clinical practice.
    Abstract

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