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Separation of basic drugs by high-performance liquid chromatography on a silica column using a
1Department of Chemistry, Loughborough University of Technology, Leics, U.K.
Journal of Chromatography
|February 17, 1989
Abstract:
The application of methanol-aqueous ethylenediamine-ammonium nitrate eluents has been investigated for the high-performance liquid chromatographic separation of basic drugs on silica stationary phases. These eluents were shown to be more reproducible than previously studied systems based on methanol-aqueous ammonia-ammonium nitrate eluents. The effects of different eluent pH and buffer concentrations have been examined.