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Updated: Mar 21, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
Published on: April 3, 2015
P-cadherin-mediated Rho GTPase regulation during collective cell migration
Cédric Plutoni1, Elsa Bazellières2, Cécile Gauthier-Rouvière3
1a Institute for Research in Immunology and Cancer, Université de Montréal , Montréal , Québec , Canada.
Abstract:
This commentary addresses the role of P-cadherin in collective cell migration (CCM), a cooperative and coordinated migration mode, used by cells during normal and pathological migration processes. We discuss how cadherin-mediated cell-cell junctions (CCJs) play a critical role in CCM through their ability to regulate Rho GTPase-dependent pathways and how this leads to the generation and orientation of mechanical forces. We will also highlight the key function of P-cadherin (a poor prognostic marker in several tumors) in promoting collective cell movement in epithelial and mesenchymal cells.
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