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Related Experiment Video

Updated: Mar 21, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

An IDH1-mutated primary gliosarcoma: case report.

Jason K Hsieh^1,2, Christopher S Hong³, Sunil Manjila⁴

¹Case Western Reserve University School of Medicine, Cleveland.

Journal of Neurosurgery

|May 7, 2016

Summary

This summary is machine-generated.

This study reports a rare primary gliosarcoma with an isocitrate dehydrogenase-1 (IDH1) mutation. This unusual genetic-histological finding in a high-grade glioma may indicate differences from typical glioblastoma.

Keywords:

EGFR = epidermal growth factor receptor GFAP = glial fibrillary acidic protein IDH1 = isocitrate dehydrogenase-1 glioblastoma gliosarcoma isocitrate dehydrogenase oncology

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Last Updated: Mar 21, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

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Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Area of Science:

Neuro-oncology
Cancer Genetics
Pathology

Background:

Gliosarcoma is a rare, aggressive variant of glioblastoma (Grade 4 glioma).
Isocitrate dehydrogenase (IDH) mutations are typically associated with lower-grade gliomas and improved survival.
IDH mutations are less commonly found in glioblastoma.

Observation:

A 75-year-old male presented with seizures and a left parietal enhancing mass on MRI.
Surgical resection revealed a high-grade glioma with sarcomatous components.
Immunohistochemistry confirmed the presence of the IDH1 R132H mutation.

Findings:

This case represents a primary gliosarcoma harboring an IDH1 mutation.
This is only the second reported instance of a primary gliosarcoma with an IDH mutation.
The tumor exhibited both glial and sarcomatous features.

Implications:

This rare genetic-histological combination challenges current understanding of glioma classification.
Potential differences between IDH-mutated gliosarcoma and IDH-mutated glioblastoma warrant further investigation.
Further research may refine diagnostic criteria and therapeutic strategies for rare gliomas.