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Related Experiment Video

Updated: Mar 21, 2026

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

Transcriptome Encyclopedia of Early Human Development.

Anna Sahakyan¹, Kathrin Plath¹

¹David Geffen School of Medicine, Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, UCLA Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.

|May 7, 2016

Summary

This summary is machine-generated.

Researchers analyzed single human embryos to understand early development. This study reveals unique features of human pre-implantation development not seen in mouse models.

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Published on: August 31, 2016

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform

Published on: January 30, 2017

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Last Updated: Mar 21, 2026

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

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Published on: August 10, 2022

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants

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Published on: August 31, 2016

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform

Published on: January 30, 2017

Area of Science:

Developmental Biology
Genomics
Reproductive Medicine

Background:

Human pre-implantation development is crucial for successful pregnancy.
Existing knowledge is limited by embryo availability and reliance on animal models.
Understanding species-specific developmental pathways is essential.

Purpose of the Study:

To provide a comprehensive transcriptome analysis of early human embryos.
To identify unique features of human pre-implantation development.
To overcome limitations of current research methods.

Main Methods:

Single-cell RNA sequencing (scRNA-seq) of a large cohort of human pre-implantation embryos.
Extensive transcriptome analysis.
Comparative analysis with existing developmental data.

Main Results:

Identification of previously unrecognized molecular features in early human development.
Detailed transcriptome profiles at single-cell resolution.
Discovery of novel developmental pathways unique to humans.

Conclusions:

This study offers unprecedented insights into early human development.
The findings highlight key differences between human and other mammalian embryonic development.
This resource will advance research in reproductive biology and developmental disorders.