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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Related Experiment Video

Updated: Mar 21, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Inflammatory Myofibroblastic Tumors: Current Update.

Venkateswar R Surabhi1, Steven Chua1, Rajan P Patel1

  • 1Department of Diagnostic and Interventional Imaging, The University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 2.130, Houston, TX 77030, USA.

Radiologic Clinics of North America
|May 8, 2016
PubMed
Summary

Inflammatory myofibroblastic tumors (IMTs) are intermediate potential neoplasms often found in the lungs and abdomen. These tumors exhibit distinct histological and molecular features, influencing their varied appearance on imaging.

Keywords:
Imaging findingsInflammatory myofibroblastic tumorsInflammatory pseudotumorLocal recurrenceMesenchymal neoplasms

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm with intermediate biological potential.
  • IMT is part of the inflammatory pseudotumor family, characterized by spindle cell proliferation and inflammation.
  • These tumors commonly occur in the lung and abdominopelvic regions.

Purpose of the Study:

  • To describe the key histological, molecular, and imaging features of inflammatory myofibroblastic tumors.
  • To differentiate IMTs from other spindle cell lesions.

Main Methods:

  • Histopathological analysis of IMT specimens.
  • Molecular characterization of IMTs.
  • Review of imaging findings in IMT cases.

Main Results:

  • IMTs display characteristic fasciitis-like, compact spindle cell, and hypocellular fibrous patterns.
  • Distinct molecular features aid in IMT diagnosis.
  • Imaging findings vary from ill-defined infiltrating lesions to well-circumscribed masses.

Conclusions:

  • IMTs are distinct neoplasms with specific histological and molecular profiles.
  • Imaging characteristics of IMTs correlate with their pathological components.
  • Understanding these features is crucial for accurate diagnosis and management.