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Updated: Mar 21, 2026

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Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?

Angelo Ferrante1, Giuliana Guggino1, Diana Di Liberto2

  • 1Dipartimento di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo, Italy.

Mechanisms of Ageing and Development
|May 8, 2016
PubMed

Endothelial Progenitor Cells (EPCs) are bone marrow derived cells able to differentiate in mature endothelial cells (EC) contributing to the generation of new vessels, connecting to fibronectin, and forming colonies and/or colony forming units. Since circulating EPCs can be actively considered part of endothelial damage in several cardiovascular diseases and autoimmune disorders the possibility to have a measure for endothelium damage should be considered of interest to predict the patient out-come. At the same time the EPCs proliferative and regenerative role could be considered for therapeutic applications. Studies have been performed to elucidate the role of EPCs in Systemic Sclerosis and many review and articles published on this topic. In the present paper we aimed to review the role of EPCs in other autoimmune disorders.

Keywords:
EPCsLESRheumatoid arthritisVasculitis

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