Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Membrane Fluidity01:26

Membrane Fluidity

17.7K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
17.7K
Membrane Fluidity01:23

Membrane Fluidity

178.8K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
178.8K
Membrane Domains01:18

Membrane Domains

8.2K
The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
8.2K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

10.9K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
10.9K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.8K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

4.0K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure and dynamics of water confined in graphene oxide.

Physical chemistry chemical physics : PCCP·2026
Same author

Multiple Shoot Bud Induction and Plant Regeneration in <i>Madhuca indica J.F.Gmel.</i>: Histological, Genetic Fidelity and GC-MS Analysis.

Plants (Basel, Switzerland)·2026
Same author

Morphology-dependent toxicity and MRI contrasting properties of Mn<sub>3</sub>O<sub>4</sub> nanostructures: A comparative study.

Biomaterials advances·2026
Same author

Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation.

Diabetes, obesity & metabolism·2026
Same author

Primary Cryptococcal Cellulitis With High Antigenemia in an Immunocompromised Host: A Case Report and Laboratory Investigation of the Causative <i>Cryptococcus neoformans</i> Strain.

Open forum infectious diseases·2026
Same author

Wound Healing and Angiogenic Profiling of Dermal Endothelial Cells Isolated From People With Type 2 Diabetes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Related Experiment Video

Updated: Mar 21, 2026

Lipid Exchange Assay in Living Cells
08:59

Lipid Exchange Assay in Living Cells

Published on: March 21, 2025

1.3K

Lipid rafts in immune signalling: current progress and future perspective.

Pallavi Varshney1,2, Vikas Yadav1, Neeru Saini1,2

  • 1Functional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.

Immunology
|May 8, 2016
PubMed
Summary

Lipid rafts are crucial platforms for immune cell signaling. Disrupting these membrane domains impacts immune responses, offering therapeutic potential for autoimmune and inflammatory diseases.

Keywords:
B/T-cell activationIgEToll-like receptorautoimmune diseasecytokine signallinglipid raftsmicroRNA

More Related Videos

Determination of Lipid Raft Partitioning of Fluorescently-tagged Probes in Living Cells by Fluorescence Correlation Spectroscopy FCS
10:59

Determination of Lipid Raft Partitioning of Fluorescently-tagged Probes in Living Cells by Fluorescence Correlation Spectroscopy FCS

Published on: April 6, 2012

16.8K
Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
10:58

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps

Published on: March 29, 2017

10.0K

Related Experiment Videos

Last Updated: Mar 21, 2026

Lipid Exchange Assay in Living Cells
08:59

Lipid Exchange Assay in Living Cells

Published on: March 21, 2025

1.3K
Determination of Lipid Raft Partitioning of Fluorescently-tagged Probes in Living Cells by Fluorescence Correlation Spectroscopy FCS
10:59

Determination of Lipid Raft Partitioning of Fluorescently-tagged Probes in Living Cells by Fluorescence Correlation Spectroscopy FCS

Published on: April 6, 2012

16.8K
Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
10:58

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps

Published on: March 29, 2017

10.0K

Area of Science:

  • Cellular Biology
  • Immunology

Background:

  • Lipid rafts are dynamic membrane microdomains involved in cellular signaling.
  • Alterations in lipid rafts are linked to human disease pathogenesis.
  • MicroRNAs can perturb raft domains by targeting raft proteins.

Purpose of the Study:

  • To review recent advancements in understanding lipid raft roles in immune signaling.
  • To explore the therapeutic potential of targeting lipid rafts for autoimmune and inflammatory disorders.

Main Methods:

  • Literature review of studies on lipid rafts and immune responses.
  • Analysis of research on microRNA-mediated perturbation of lipid rafts.
  • Examination of evidence linking lipid raft disruption to immune cell activation and cytokine secretion.

Main Results:

  • Lipid rafts serve as signaling platforms for immune receptors on B cells, T cells, basophils, and mast cells.
  • Ligand binding to these receptors initiates signaling cascades, leading to inflammation.
  • Disruption of lipid raft integrity affects lipopolysaccharide-induced cytokine secretion, IgE signaling, and B-cell and T-cell activation.

Conclusions:

  • Lipid rafts play a significant role in modulating both innate and acquired immunity.
  • Targeting lipid rafts presents a promising therapeutic strategy for autoimmune diseases and inflammatory conditions.