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Penile melanosis.

J Revuz1, T Clerici

  • 1Services de Dermatologie, Université Paris XII, Hôpital Henri Mondor, Créteil, France.

Journal of the American Academy of Dermatology
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

Penile melanosis presents as benign macular hyperpigmentation on the penis. This condition shares features with other mucosal melanoses, suggesting a unified classification of essential melanotic hyperpigmentation.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Penile melanosis is a rare condition characterized by macular hyperpigmentation of the penile shaft and/or glans.
  • Histological examination reveals basal cell layer hyperpigmentation without melanocytic hyperplasia.

Purpose of the Study:

  • To describe clinical and histological features of penile melanosis.
  • To differentiate penile melanosis from other conditions, particularly acral lentiginous melanoma.
  • To propose a unified classification for related mucosal melanotic conditions.

Main Methods:

  • Case series describing five patients with penile melanosis.
  • Clinical observation of lesion characteristics and follow-up.
  • Histopathological analysis of biopsy specimens.

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Main Results:

  • Observed macular hyperpigmentation on the penile shaft and/or glans in all five patients.
  • Histology confirmed basal cell layer hyperpigmentation, with no evidence of melanocytic hyperplasia.
  • Long-term follow-up (3-13 years) indicated benign progression, with some lesion enlargement but no malignant transformation.
  • Differential diagnosis highlighted the challenge of distinguishing from acral lentiginous melanoma.

Conclusions:

  • Penile melanosis is a benign condition characterized by hyperpigmentation.
  • Penile melanosis shares clinical and microscopic similarities with Laugier-Hunziker syndrome and vulvovaginal melanosis.
  • These conditions may represent a spectrum of essential melanotic hyperpigmentation of mucosa.