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Updated: Mar 21, 2026
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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
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Using peptides to increase transport across the intestinal barrier
M Sánchez-Navarro1, J Garcia1, E Giralt2
1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac, 10, 08028 Barcelona, Spain.
Advanced Drug Delivery Reviews
|May 8, 2016
Summary
Peptides offer a promising solution to improve oral drug delivery by enhancing intestinal absorption. This review explores peptide sources, mechanisms, safety, and formulation strategies for better drug permeability.
Area of Science:
- Pharmacology
- Drug Delivery
- Biotechnology
Background:
- Oral drug administration is preferred but limited by poor intestinal permeability.
- Enhancing drug absorption across the intestinal barrier is a significant challenge in pharmaceutical development.
Purpose of the Study:
- To review the use of peptides as enhancers for intestinal drug absorption.
- To analyze sources, mechanisms, toxicity, and formulation of peptide enhancers.
Main Methods:
- Literature review of studies on peptide-mediated intestinal absorption.
- Analysis of peptide sources and absorption mechanisms.
- Evaluation of toxicological data and formulation approaches.
Main Results:
- Various peptide sources can be utilized to enhance drug permeability.
- Peptides employ diverse mechanisms to facilitate drug absorption.
- Potential toxic effects and formulation strategies require careful consideration.
Conclusions:
- Peptides present a viable strategy for improving oral drug bioavailability.
- Further research is needed to optimize peptide-based delivery systems and ensure safety.
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