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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...

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Related Experiment Video

Updated: Mar 21, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

Livedoid vasculopathy - a challenging disease.

R Vieira, J M Bernardes, J A Pinto

Acta Reumatologica Portuguesa

|May 8, 2016

Summary

Idiopathic livedoid vasculopathy (LV) associated with peripheral sensory neuropathy was successfully treated with immunotherapy. This suggests B cells play a role in the condition

Area of Science:

Vascular Medicine
Neurology
Immunology

Background:

Idiopathic livedoid vasculopathy (LV) is a rare condition characterized by painful skin ulcers.
The exact cause of LV remains unclear, but it is thought to involve blood vessel abnormalities.
Peripheral sensory neuropathy involves damage to nerves responsible for sensation.

Observation:

A rare case of idiopathic livedoid vasculopathy (LV) co-occurring with peripheral sensory neuropathy was observed.
The patient presented with symptoms of both conditions, indicating a potential link.

Findings:

Initial treatment with intravenous immunoglobulin and warfarin showed limited success.
Subsequent treatment with rituximab resulted in an excellent clinical response.

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Last Updated: Mar 21, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

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This suggests B cells may be critically involved in the pathogenesis of LV.

Implications:

The findings suggest B-cell targeted therapy could be a viable treatment option for LV.
Further research into the immunological mechanisms of LV is warranted.
This case highlights the importance of considering associated neurological conditions in LV patients.