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Regulation of the TGF-β pathway by deubiquitinases in cancer

Sijia Liu1, Miriam de Boeck1, Hans van Dam1

  • 1Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden University Medical Centre, Leiden, The Netherlands.

The International Journal of Biochemistry & Cell Biology
|May 8, 2016
PubMed

Insights

Deubiquitinases (DUBs) regulate the transforming growth factor-β (TGF-β) pathway. Dysfunctional DUBs disrupt TGF-β signaling, promoting cancer progression and metastasis, highlighting DUBs as potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Cancer Biology

Background:

  • The transforming growth factor-β (TGF-β) pathway is crucial for cellular functions.
  • Aberrant TGF-β signaling in cancer drives invasion, metastasis, and epithelial-to-mesenchymal transition (EMT).
  • Targeting pro-oncogenic TGF-β responses is a developing cancer therapy strategy.

Purpose of the Study:

  • To review the role of deubiquitinases (DUBs) in regulating TGF-β signaling.
  • To explore how DUBs control Smad and non-Smad TGF-β pathways.
  • To understand DUBs' contribution to TGF-β misregulation in cancer.

Main Methods:

  • Literature review focusing on deubiquitinases (DUBs).
  • Analysis of DUBs' mechanisms in controlling TGF-β pathway components.
  • Examination of DUBs' role in cancer-associated TGF-β dysregulation.

Main Results:

  • Deubiquitinases (DUBs) are key regulators of TGF-β pathway components via the ubiquitin system.
  • Specific DUBs modulate both Smad and non-Smad signaling arms of the TGF-β pathway.
  • Altered DUB expression or function leads to TGF-β pathway misregulation in cancer.

Conclusions:

  • Deubiquitinases (DUBs) play a critical role in controlling TGF-β signaling.
  • DUBs are implicated in the development and progression of various cancers.
  • Targeting DUBs offers a promising avenue for cancer therapy by modulating TGF-β responses.
Keywords:
CancerDeubiquitinaseSmadTGF-βUbiquitin

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