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GPCRdb: the G protein-coupled receptor database - an introduction
C Munk1, V Isberg1, S Mordalski2
1Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
British Journal of Pharmacology
|May 9, 2016
Summary
GPCRdb provides integrated data and web tools for G protein-coupled receptors (GPCRs), aiding drug design. This review details GPCRdb services for researchers studying these crucial membrane proteins and drug targets.
Area of Science:
- Biochemistry and structural biology
- Pharmacology and drug discovery
- Bioinformatics and computational biology
Background:
- G protein-coupled receptors (GPCRs) represent the largest human membrane protein family and are key drug targets.
- Advances in GPCR pharmacology and crystallography illuminate signal transduction, allosteric modulation, and biased signaling, informing novel drug design principles.
- The GPCR database (GPCRdb) has supported the research community for over two decades and now caters to a broader, multidisciplinary audience.
Purpose of the Study:
- To introduce new users to the comprehensive services offered by GPCRdb.
- To highlight GPCRdb's role in providing integrated, annotated reference data on GPCRs, including sequences, structures, mutations, and ligand interactions.
- To showcase GPCRdb's suite of web tools for analyzing GPCR structures, sequences, relationships, and ligand profiles, and to describe its dissemination of interactive data visualizations.
Main Methods:
- Data integration and annotation of GPCR information, focusing on sequences, structures, mutations, and ligand interactions.
- Development and description of web-based tools for analyzing GPCR data, including structural and sequence analysis, receptor relationships, and ligand target profiling.
- Creation of interactive diagrams for visualizing GPCR residue topologies, phylogenetic relationships, and crystal structure statistics.
Main Results:
- GPCRdb offers a unified platform for accessing structured reference data on GPCRs.
- A suite of web tools is available for rapid analysis of GPCR sequences, structures, and ligand interactions.
- Interactive visualizations facilitate the understanding of GPCR properties and relationships.
Conclusions:
- GPCRdb serves as an essential resource for researchers studying G protein-coupled receptors.
- The database and its associated tools empower the scientific community with data and analytical capabilities for GPCR research and drug design.
- GPCRdb facilitates the dissemination of knowledge through accessible data presentation and cross-referenced complementary resources.
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