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Enterovirus and parechovirus infection in children: a brief overview

S C M de Crom1,2, J W A Rossen3, A M van Furth4

  • 1Department of Pediatrics, St. Elisabeth Hospital, Tilburg, The Netherlands. stephanie_de_crom@hotmail.com.

European Journal of Pediatrics
|May 9, 2016
PubMed

Insights

Enterovirus (EV) and parechovirus (HPeV) frequently infect children, presenting diverse symptoms. While no specific treatment exists, RT-qPCR offers the best detection, and new vaccines are emerging for EV 71.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Enteroviruses (EV) and parechoviruses (HPeV) are common causes of childhood infections.
  • This review synthesizes current knowledge on EV and HPeV infections in pediatric populations.

Purpose of the Study:

  • To provide a comprehensive overview of enterovirus and parechovirus infections in children.
  • To cover epidemiology, pathogenesis, clinical manifestations, diagnostic methods, treatment options, and prognosis.

Main Methods:

  • Literature review synthesizing existing research on pediatric EV and HPeV infections.
  • Focus on epidemiology, clinical presentation, diagnosis, treatment, and prognosis.

Main Results:

  • EV and HPeV infections are frequent in children with varied clinical presentations.
  • RT-qPCR is the preferred diagnostic method, with high sensitivity in cerebrospinal fluid, blood, and feces.
  • No specific treatment is currently available, although EV 71 vaccines are newly licensed in China.

Conclusions:

  • EV and HPeV infections are common pediatric concerns with diverse clinical outcomes.
  • Early and accurate diagnosis via RT-qPCR is crucial.
  • The long-term prognosis of these infections requires further investigation.
Abstract

Keywords:
ChildrenEnterovirusInfectionOverviewParechovirus

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