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Effects of Hepatitis C Virus Infection on Human Sperm Chromosomes

Yijian Zhu, Mingfu Ma, Jihua Huang

    Clinical Laboratory
    |May 10, 2016
    PubMed

    Insights

    Hepatitis C virus (HCV) infection significantly increases chromosomal aberrations in sperm, indicating potential mutagenic and hereditary effects. This finding highlights the risk of genetic alterations and possible germline transmission of HCV.

    Area of Science:

    • Reproductive Biology
    • Genetics
    • Hepatology

    Background:

    • Hepatitis C virus (HCV) infection is a global health concern.
    • Sperm chromosomal aberrations may impact male fertility and offspring health.
    • The mutagenic potential of HCV on sperm chromosomes requires investigation.

    Purpose of the Study:

    • To quantify chromosomal aberrations in sperm from men with Hepatitis C virus (HCV) infection.
    • To compare sperm chromosome integrity between HCV-infected individuals and healthy controls.
    • To assess the potential mutagenic and hereditary effects of HCV on sperm.

    Main Methods:

    • Sperm samples were collected from 36 men (16 with HCV, 20 healthy controls).
    • Interspecies in vitro fertilization using zona-free golden hamster ova was performed.
    • Frequencies of spermatozoan chromosomal aberrations were analyzed and compared between groups.

    Main Results:

    • Sperm from HCV-infected men exhibited a significantly higher rate of chromosomal aberrations (10.85%) compared to controls (5.96%).
    • HCV-infected sperm showed increased anomalies like stickiness and clumping, hindering analysis.
    • A statistically significant difference (p < 0.01) was observed between the groups.

    Conclusions:

    • Hepatitis C virus infection demonstrates mutagenic effects on sperm chromosomes.
    • These genetic alterations may lead to extensive hereditary effects in offspring.
    • Vertical transmission of HCV via the germline is a potential concern.
    Abstract

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