Enantioseparations of pharmaceuticals with capillary electrochromatography: A review

The chiral separation of pharmaceuticals is one of the major research topics in the pharmaceutical industry. Chromatographic techniques are most frequently used in this context. Separations in capillary electrochromatography (CEC) are an alternative and achieved by chromatographic retention and electrophoretic mobility principles. As a result, CEC is characterized by a high selectivity and efficiency. The limited number of stationary phases specifically developed for CEC, the low number of commercially available CEC columns, the frits to maintain the stationary phase, which forms fragile spots in the columns, and the limited column robustness and reproducibility, make CEC not very attractive for industrial application. However, CEC is still applied and studied in the academic field. This review discusses the enantioseparation of drugs in CEC published during the last four years, with a critical view on the reproducibility and the practical utility of these applications.