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Updated: Mar 21, 2026
Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy
Published on: May 3, 2019
Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery
Antonello Enrico Spinelli1, Marco P Schiariti2, Chiara M Grana3
1San Raffaele Scientific Institute, Experimental Imaging Centre, Via Olgettina N. 60, Milan 20182 Italy.
Abstract:
We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of 90Y-DOTATOC the day before neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f ∕0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery.
