Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

555
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
555
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

643
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
643
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

775
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
775
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

733
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
733
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

873
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
873
Development of the Heart01:27

Development of the Heart

3.4K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the contribution of rare variants to congenital heart disease through a large-scale case-control exome study.

NPJ genomic medicine·2026
Same author

Lowered Maternal and Paternal Plasma Concentrations of Choline Are Associated with the Severity of Congenital Heart Defects in the Offspring.

Nutrients·2026
Same author

Genetic alterations in poor-quality individually selected sperm highlight candidate biomarkers for male subfertility.

Scientific reports·2026
Same author

Malposition of a Port Catheter in the Azygos Vein: Endovascular Repositioning Using a Long Loop Snare Technique.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026
Same author

Over-the-wire insertion of a naso-duodenal feeding tube in a critically ill infant.

JPGN reports·2026
Same author

DNA methylation analysis of NOTCH1 variants reveals the first episignature for non-syndromic congenital heart defects.

Genome medicine·2026

Related Experiment Video

Updated: Mar 21, 2026

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
07:48

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

Published on: May 24, 2016

20.1K

Preterm Birth Is Associated with Altered Myocardial Function in Infancy.

Ulf Schubert1, Matthias Müller2, Hashim Abdul-Khaliq2

  • 1Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|May 10, 2016
PubMed
Summary

Very preterm infants show altered left ventricular function by 6 months after birth. Further research is needed to understand the long-term cardiovascular health implications for these children.

Keywords:
Cardiac functionPreterm infantSpeckle-tracking echocardiography

More Related Videos

Noninvasive Electrocardiography in the Perinatal Mouse
04:36

Noninvasive Electrocardiography in the Perinatal Mouse

Published on: June 12, 2020

6.8K
Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

3.9K

Related Experiment Videos

Last Updated: Mar 21, 2026

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
07:48

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

Published on: May 24, 2016

20.1K
Noninvasive Electrocardiography in the Perinatal Mouse
04:36

Noninvasive Electrocardiography in the Perinatal Mouse

Published on: June 12, 2020

6.8K
Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

3.9K

Area of Science:

  • Neonatal cardiology
  • Pediatric cardiovascular research
  • Fetal development and cardiac function

Background:

  • Preterm birth is linked to myocardial remodeling and accelerated cardiovascular aging.
  • The precise mechanisms driving these long-term cardiac changes remain unclear.
  • Echocardiography is a key tool for assessing infant myocardial function.

Purpose of the Study:

  • To sequentially analyze myocardial function in very preterm infants.
  • To compare cardiac performance in very preterm infants versus term-born infants.
  • To identify early indicators of potential cardiovascular complications.

Main Methods:

  • Speckle-tracking echocardiography was used to evaluate myocardial deformation and velocity.
  • Cardiac function was assessed in 25 very preterm infants (26-30 weeks gestation) at birth, 3, and 6 months corrected age.
  • Results were compared to 30 term-born infants assessed at birth and 3 months.

Main Results:

  • Left ventricular longitudinal strain and diastolic myocardial velocities were significantly lower in very preterm infants at 6 months corrected age.
  • No significant differences were observed in right ventricular or interventricular septal measurements between groups.
  • Conventional echocardiographic variables did not differ significantly at any time point.

Conclusions:

  • Very preterm infants exhibit altered left ventricular myocardial function 6 months post-birth.
  • Longitudinal follow-up is crucial to determine the cardiovascular health implications for survivors of very preterm birth.
  • Early detection of myocardial changes may inform future preventative strategies.