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Carbonic anhydrase IX deposits are associated with increased ascending aortic dilatation

Eetu Niinimaki1, Petteri Muola1, Seppo Parkkila1,2

  • 1b School of Medicine , University of Tampere , Tampere , Finland ;

Scandinavian Cardiovascular Journal : SCJ
|May 10, 2016
PubMed

Insights

Carbonic anhydrase IX (CA IX) deposits in the aorta are linked to increased inflammation and size. This suggests elevated CA IX activity may contribute to ascending aortic dilatation.

Area of Science:

  • Cardiovascular Research
  • Pathology
  • Biochemistry

Background:

  • Carbonic anhydrase IX (CA IX) expression is a known marker of local hypoxia.
  • Ascending aortic dilatation is a serious cardiovascular condition often associated with inflammation and tissue remodeling.

Purpose of the Study:

  • To investigate the association between carbonic anhydrase IX (CA IX) deposits and ascending aortic dilatation.
  • To explore the relationship between CA IX expression and adventitial inflammation in the ascending aorta.

Main Methods:

  • Histological analysis of ascending aorta specimens from 30 surgical patients.
  • Assessment of CA IX expression, inflammatory cell presence (leukocytes, plasma cells, macrophages), smooth muscle cells, cell proliferation, elastin, and collagen.
  • Grouping of samples based on the presence or absence of CA IX deposits.

Main Results:

  • CA IX-positive deposits were found in the adventitia of 20 out of 30 patients.
  • CA IX-positive samples exhibited significantly increased adventitial inflammation compared to CA IX-negative samples (p < 0.01).
  • Patients with CA IX-positive staining showed a significantly larger mean ascending aorta diameter (63 ± 3 mm vs 53 ± 2 mm, p < 0.02), confirmed by ROC analysis (AUC 0.766, p = 0.020).

Conclusions:

  • The presence of CA IX deposits in aortic specimens is associated with ascending aortic dilatation.
  • Increased carbonic anhydrase (CA) activity, indicated by CA IX positivity, may play a role in the pathogenesis of ascending aortic dilatation.
Abstract

Keywords:
Ascending aortic dilatationCA IXinflammation

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