Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.2K
Bone Disorders01:29

Bone Disorders

6.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
6.6K
Bone Remodeling01:40

Bone Remodeling

41.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.0K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

7.0K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
7.0K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.9K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.9K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

7.3K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral Infigratinib Therapy in Children with Achondroplasia.

The New England journal of medicine·2024
Same author

Adult height improved over decades in patients with X-linked hypophosphatemia: a cohort study.

European journal of endocrinology·2023
Same author

Infigratinib in children with achondroplasia: the PROPEL and PROPEL 2 studies.

Therapeutic advances in musculoskeletal disease·2022
Same author

Diagnostic yield of bone fragility gene panel sequencing in children and young adults referred for idiopathic primary osteoporosis at a single regional reference centre.

Bone reports·2022
Same author

WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis.

Human molecular genetics·2021
Same author

SNORD116 and growth hormone therapy impact IGFBP7 in Prader-Willi syndrome.

Genetics in medicine : official journal of the American College of Medical Genetics·2021

Related Experiment Video

Updated: Mar 21, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.6K

Bone metabolism during pregnancy.

Jean Pierre Salles1

  • 1Unité d'endocrinologie, maladies osseuses, génétique et gynécologie, hôpital des Enfants, CHU de Toulouse, TSA 70034, 31059 Toulouse cedex 09, France; Inserm UMR 1043 (Centre de physiopathologie de Toulouse-Purpan, CPTP), université de Toulouse-Paul-Sabatier, 31059 Toulouse, France.

Annales D'Endocrinologie
|May 10, 2016
PubMed
Summary

Pregnancy and lactation involve significant maternal bone mineral regulation, primarily involving calcium and phosphorus, to support fetal development and milk production. Hormonal shifts ensure adequate mineral transfer, with physiological bone loss usually not causing fractures.

Keywords:
GrossesseLactationNewbornNouveau-néOsteoporosisOstéoporoseParathyroid hormone-related proteinPregnancy

More Related Videos

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.8K
Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

2.6K

Related Experiment Videos

Last Updated: Mar 21, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.6K
Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.8K
Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

2.6K

Area of Science:

  • Endocrinology
  • Mineral Metabolism
  • Reproductive Physiology

Background:

  • Pregnancy requires high maternal calcium and phosphorus levels for fetal skeletal development.
  • Maternal adaptations include increased intestinal absorption and placental mineral transport.
  • Parathyroid hormone (PTH), PTH-related protein (PTHrP), and calcitriol are key regulators of mineral homeostasis.

Purpose of the Study:

  • To elucidate the hormonal and physiological mechanisms governing maternal mineral balance during pregnancy and lactation.
  • To understand the regulation of calcium and phosphorus homeostasis in the context of fetal and neonatal demands.
  • To differentiate physiological bone changes from pathological conditions like osteoporosis.

Main Methods:

  • Review of existing literature on mineral metabolism during reproduction.
  • Analysis of hormonal regulation involving PTH, PTHrP, calcitriol, and the calcium-sensing receptor (CaSR).
  • Examination of skeletal adaptations during pregnancy, postpartum, and lactation.

Main Results:

  • Maternal skeleton resorbs bone via PTHrP if calcium intake is insufficient.
  • Postnatal adaptation involves increased PTH and calcitriol, with bone turnover contributing minerals.
  • Lactation induces programmed bone loss through a "brain-breast-bone" circuit to supply calcium for milk.

Conclusions:

  • Physiological bone resorption during reproduction is typically transient and does not lead to fractures.
  • Fractures in women during reproductive years suggest underlying causes beyond normal physiological bone loss.
  • Identification of primary osteoporosis is crucial in cases presenting with fractures.