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Published on: August 23, 2019
ApolipoproteinL1 is expressed in papillary thyroid carcinomas.
Mounia Chidiac1, Mohammad Fayyad-Kazan2, Jalil Daher2
1Institute for Molecular Biology and Medicine (IBMM), Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium; Laboratory of Immunology, Department of Biochemistry, Faculty of Sciences, Lebanese University, Hadath, Beirut 21219, Lebanon.
Apolipoprotein L1 (apoL1) is overexpressed in papillary thyroid carcinoma. This finding suggests a potential role for apoL1 in cancer development, warranting further investigation into its function in cell death.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- The apolipoprotein L (apoL) family's function is unclear, but a conserved BH3 domain suggests involvement in programmed cell death.
- Repression of apoptosis is a key feature of tumor progression.
Purpose of the Study:
- To investigate apolipoprotein L family expression in cancer.
- Specifically, to examine apolipoprotein L1 (apoL1) expression in papillary thyroid carcinoma.
Main Methods:
- Quantitative reverse transcription PCR (qRTPCR).
- Immunohistochemistry.
- In situ hybridization.
Main Results:
- Apolipoprotein L1 (apoL1) levels are elevated in papillary thyroid carcinoma compared to normal tissue.
- This overexpression originates from carcinoma cells.
Conclusions:
- Apolipoprotein L1 (apoL1) is upregulated in papillary thyroid carcinoma.
- Further research is ongoing to determine if apoL1 actively prevents cell death, contributing to cancer progression.
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