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Updated: Mar 21, 2026
10:24
Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
Published on: October 28, 2014
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Localization and function of the renal calcium-sensing receptor
Daniela Riccardi1, Giovanna Valenti2
1Division of Pathophysiology and Repair, School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
Nature Reviews. Nephrology
|May 10, 2016
Summary
The calcium-sensing receptor (CaSR) detects extracellular calcium levels, regulating parathyroid hormone secretion. The kidney
Area of Science:
- Physiology
- Endocrinology
- Molecular Biology
Background:
- Organisms possess mechanisms to monitor extracellular ionic composition.
- The calcium-sensing receptor (CaSR) was identified as a cellular ion-sensing mechanism in the 1990s.
- CaSR detects extracellular calcium (Ca2+) and regulates parathyroid hormone (PTH) secretion.
Purpose of the Study:
- To review the roles of the renal CaSR.
- To discuss the potential impact of CaSR modulation on renal function.
Main Methods:
- Literature review of CaSR research.
- Analysis of CaSR's role in kidney physiology.
- Discussion of calcimimetics and calcilytics.
Main Results:
- CaSR in parathyroid glands regulates PTH secretion and calcium homeostasis.
- Dysfunctional CaSR leads to impaired divalent cation balance.
- Calcimimetics treat hyperparathyroidism; calcilytics are in development for hypercalciuric disorders.
Conclusions:
- The kidney expresses CaSR, potentially regulating renal function independently of PTH.
- Pharmacological targeting of renal CaSR offers therapeutic possibilities for kidney disorders.
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