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Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

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Updated: Mar 21, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Published on: July 16, 2018

Microarray-based Gene Expression Profiling of Abdominal Aortic Aneurysm.

H Z Butt¹, N Sylvius¹, M K Salem¹

¹Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery

|May 10, 2016

Summary

This summary is machine-generated.

Gene expression in abdominal aortic aneurysms (AAA) differs from controls, with specific genes showing altered levels. These changes, related to inflammation and cell death, are linked to AAA pathogenesis and repair.

Keywords:

Abdominal aortic aneurysm Biological markers Gene expression Microarray RNA Transcriptome

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Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

Area of Science:

Molecular Biology
Genomics
Vascular Biology

Background:

Abdominal aortic aneurysms (AAA) are characterized by complex molecular changes.
Gene expression profiling offers potential for identifying prognostic biomarkers in AAA.

Purpose of the Study:

To compare peripheral blood gene expression between individuals with AAA and controls.
To identify differentially expressed genes and pathways involved in AAA pathogenesis.

Main Methods:

Microarray analysis of peripheral blood transcriptome in 12 AAA patients and 12 controls.
Validation of 11 differentially expressed genes using quantitative PCR in independent cohorts, including pre- and post-repair patients and tissue samples.

Main Results:

Microarray identified 47 significantly differentially expressed genes in AAA, involved in apoptosis, proteolysis, and immune response.
Validation confirmed downregulation of MSN, PSMB10, and STIM1 in AAA patients; PSMB10 showed consistent downregulation.
Expression of 11 key genes was detected in aortic biopsies and smooth muscle cells.

Conclusions:

Peripheral blood transcriptomic analysis reveals differential gene expression in AAA patients.
Identified genes and pathways (proteolysis, inflammation, apoptosis) are implicated in AAA pathogenesis.
Gene expression changes are modulated by aneurysm repair and present in aortic tissues.