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Updated: Mar 21, 2026
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Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
Published on: April 14, 2011
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Quantum dot-NanoLuc bioluminescence resonance energy transfer enables tumor imaging and lymph node mapping in vivo
Anyanee Kamkaew1, Haiyan Sun1, Christopher G England1
1Departments of Radiology and Medical Physics, University of Wisconsin-Madison, WI 53705, USA. wcai@uwhealth.org.
Chemical Communications (Cambridge, England)
|May 10, 2016
Abstract:
A small luciferase protein (Nluc) was conjugated to QDs as a bioluminescence resonance energy transfer (BRET) pair. The conjugate showed 76% BRET efficiency and lymph node mapping was successfully performed. The cRGD peptide was conjugated to QD-Nluc for tumor targeting. The self-illuminating QD-Nluc showed excellent energy transfer in a living system and offered an optimal tumor-to-background ratio (>85).
