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Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma: possible recent trend

Anupam Mishra1, Monica Sachadeva1, Ankita Jain1

  • 1Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow.

American Journal of Otolaryngology
|May 10, 2016
PubMed

Insights

This study investigates the potential link between human papillomavirus (HPV) and juvenile nasopharyngeal angiofibroma (JNA), finding HPV universally present in JNA tissues but not in controls.

Area of Science:

  • Otolaryngology
  • Oncology
  • Virology

Background:

  • Juvenile nasopharyngeal angiofibroma (JNA) incidence has increased significantly.
  • Human papillomavirus (HPV) is prevalent in oropharyngeal cancers, particularly in India.
  • The potential role of HPV in JNA pathogenesis remains unexplored.

Purpose of the Study:

  • To investigate the presence and association of HPV in juvenile nasopharyngeal angiofibroma (JNA).
  • To explore a potential link between HPV infection and JNA development.

Main Methods:

  • Clinico-surgical data from 6 JNA patients were analyzed.
  • Tissue samples underwent Western blotting, PCR, and immunofluorescence for HPV detection.
  • Control nasopharyngeal tissue (adenoids) from 6 individuals were analyzed via Western blotting.

Main Results:

  • Human papillomavirus (HPV) was universally detected in JNA tissue samples.
  • A single JNA case showed only weak HPV infection.
  • No HPV was detected in the control nasopharyngeal tissue samples.

Conclusions:

  • A novel discovery suggests a definite association between HPV and JNA.
  • Further research is warranted to elucidate the implications of this association.
  • The findings open new avenues for understanding JNA etiology.
Abstract

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