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Updated: Mar 21, 2026

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts
Published on: December 1, 2018
Single realization stochastic FDTD for weak scattering waves in biological random media
Tengmeng Tan1, Allen Taflove2, Vadim Backman1
1Robert R. McCormick School of Engineering and Applied Science, Northwestern University, Department of Biomedical Engineering, 2145 Sheridan Rd., Evanston, Illinois 60208-3107.
Abstract:
This paper introduces an iterative scheme to overcome the unresolved issues presented in S-FDTD (stochastic finite-difference time-domain) for obtaining ensemble average field values recently reported by Smith and Furse in an attempt to replace the brute force multiple-realization also known as Monte-Carlo approach with a single-realization scheme. Our formulation is particularly useful for studying light interactions with biological cells and tissues having sub-wavelength scale features. Numerical results demonstrate that such a small scale variation can be effectively modeled with a random medium problem which when simulated with the proposed S-FDTD indeed produces a very accurate result.
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