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Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

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Black ginseng extract ameliorates hypercholesterolemia in rats.

Evelyn Saba¹, Bo Ra Jeon¹, Da-Hye Jeong¹

¹Laboratory of Veterinary Physiology and Cell Signaling, Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.

Journal of Ginseng Research

|May 10, 2016

Summary

Black ginseng (BG) extracts effectively lowered high cholesterol and LDL levels in rats by regulating genes involved in fat metabolism and reducing fat accumulation, suggesting cardioprotective benefits.

Keywords:

black ginseng hypercholesterolemia lipogenesis messenger RNA

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Area of Science:

Pharmacology and Traditional Medicine
Biochemistry and Molecular Biology
Nutritional Science

Background:

Ginseng (Panax ginseng Meyer) is a revered medicinal herb with diverse therapeutic properties.
Black ginseng (BG), produced by repeated steaming, exhibits enhanced antioxidant activity.
Previous studies suggest BG influences lipid profiles, prompting investigation into its effects on hypercholesterolemia.

Purpose of the Study:

To investigate the effects of water and ethanol extracts of Black ginseng (BG) on hypercholesterolemia in rats.
To determine the impact of BG extracts on cholesterol metabolism and related gene expression.
To assess the histological changes in liver and adipose tissues following BG administration.

Main Methods:

Male Sprague Dawley rats were fed a high-cholesterol diet supplemented with BG extracts (200 mg/kg).
Measurements included serum cholesterol, white blood cell counts, and cholesterol-metabolizing gene mRNA expression.
Histological analysis of liver and adipose tissues was performed using hematoxylin and eosin and oil red O staining.

Main Results:

BG extracts significantly reduced total serum cholesterol and low-density lipoprotein (LDL) levels.
Administration of BG extracts increased food efficiency ratio and neutrophil cell count.
BG extracts downregulated mRNA expression of key lipogenic genes (e.g., HMGCR, SREBP-2) and reduced fat accumulation in liver and adipose tissues.

Conclusions:

Black ginseng extracts ameliorated hypercholesterolemia in rats fed a high-cholesterol diet.
The cardioprotective effects of BG are likely mediated by modulating cholesterol-metabolizing marker genes.
This study provides the first report on the efficacy of BG extracts in managing hypercholesterolemia.