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BRD7: a novel tumor suppressor gene in different cancers
Xin Yu1, Zheng Li2, Jianxiong Shen2
1Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100042, China.
Abstract:
BRD7 (bromodomain 7), also known as celtix-1, was first identified in nasopharyngeal carcinoma (NPC) cells in 2000. BRD7 is a crucial component of both functional p53 and BRCA1 (breast cancer 1, early onset) pathways. Recently, the BRD7 tumor suppressor status has been fully established. Previous studies demonstrated that BRD7 was downregulated in human breast cancer and the downregulation often associates with tumor progression. The expression of BRD7 was downregulated in various cancers, including breast cancer, NPC, gastric cancer, colorectal carcinoma, ovarian cancer, and prostate cancer. Moreover, BRD7 inhibited cancer cell growth and metastasis and promote apoptosis in vitro and in vivo via downregulating AKT pathway. In addition, BRD7 may regulate many signaling pathways including ras-raf-MEK-ERK and RB/E2F. In this review, we provide an overview of current knowledge concerning the role of BRD7 in tumor development and progression. To our knowledge, this is the first review about the role of this novel tumor suppressor gene BRD7in tumor development and progression.
Insights
Bromodomain 7 (BRD7) acts as a tumor suppressor, inhibiting cancer growth and metastasis across multiple cancer types. Its downregulation is linked to tumor progression, highlighting its critical role in cancer development.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Bromodomain 7 (BRD7) was first identified in nasopharyngeal carcinoma (NPC) cells.
- BRD7 functions as a tumor suppressor and is a component of p53 and BRCA1 pathways.
- BRD7 downregulation is observed in various cancers, including breast, NPC, gastric, colorectal, ovarian, and prostate cancers, and correlates with tumor progression.
Purpose of the Study:
- To review the current knowledge on the role of BRD7 in tumor development and progression.
- To consolidate findings on BRD7 as a novel tumor suppressor gene.
Main Methods:
- Literature review of studies investigating BRD7 expression and function in cancer.
- Analysis of BRD7's involvement in key signaling pathways (AKT, ras-raf-MEK-ERK, RB/E2F).
Main Results:
- BRD7 inhibits cancer cell growth, metastasis, and promotes apoptosis in vitro and in vivo.
- BRD7 downregulation is associated with tumor progression in multiple human cancers.
- BRD7 influences critical cancer-related signaling pathways.
Conclusions:
- BRD7 is a significant tumor suppressor gene with a critical role in preventing cancer development and progression.
- Targeting BRD7 or understanding its regulatory pathways may offer novel therapeutic strategies for various cancers.
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