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Prenatally Diagnosed Aggressive Intracranial Immature Teratoma-Clinicopathological Correlation
Hiroki Nariai1, Dana E Price2, Ajit Jada3
1a Neurology, Montefiore Hospital and Medical Center , Bronx , NY , USA.
Objective:
To describe clinicopathological correlation of congenital intracranial immature teratoma.
Methods:
A retrospective case analysis from a tertiary medical center.
Results:
We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index.
Conclusion/Implications:
Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.
