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An elastic second skin.

Betty Yu1, Soo-Young Kang1, Ariya Akthakul2

  • 1Living Proof, Inc., Cambridge, Massachusetts 02142, USA.

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|May 10, 2016
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Summary
This summary is machine-generated.

A new elastic, wearable crosslinked polymer layer (XPL) mimics youthful skin properties. Applied topically, XPL improved the appearance of under-eye herniations in a pilot study.

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Area of Science:

  • Biomaterials Science
  • Dermatology
  • Polymer Chemistry

Background:

  • Aging and various conditions compromise skin barrier function and elasticity.
  • Existing treatments for skin laxity and herniation often involve invasive procedures.
  • There is a need for non-invasive, wearable solutions that restore skin-like properties.

Purpose of the Study:

  • To synthesize and characterize an elastic, wearable crosslinked polymer layer (XPL) that mimics youthful skin.
  • To evaluate the performance and efficacy of XPL in a pilot human study for cosmetic improvement.
  • To explore the potential applications of XPL in skin repair and drug delivery.

Main Methods:

  • Synthesis of a tunable polysiloxane-based material for XPL with controlled elasticity, contractility, adhesion, tensile strength, and occlusivity.
  • Topical application of XPL, which cures rapidly at the skin interface without external activation.
  • Pilot human study involving 12 subjects with lower eyelid fat pad herniation, assessing XPL performance using a 5-point severity scale.

Main Results:

  • XPL demonstrated a tensile modulus matching normal skin at low strain (<40%) and withstood elongations >250% with elastic recoil.
  • Topical application of XPL to herniated lower eyelid fat pads resulted in an average 2-grade decrease in herniation appearance.
  • The material showed tunable properties, allowing for engineering specific mechanical and barrier functions.

Conclusions:

  • The developed elastic, wearable crosslinked polymer layer (XPL) effectively mimics key properties of youthful skin.
  • XPL shows promise as a non-invasive cosmetic treatment for skin laxity and herniation, with potential for broader dermatological applications.
  • The XPL platform offers a versatile solution for compromised skin barrier function, pharmaceutical delivery, and wound dressings.