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Study of shellac glycerol esters as microencapsulating materials.

V D Labhasetwar1, P K Puranik, A K Dorle

  • 1Department of Pharmaceutical Sciences, Nagpur University Campus, India.

Journal of Microencapsulation
|January 1, 1989
PubMed
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Shellac esters offer improved sustained release formulations compared to traditional shellac. These novel esters enhance drug delivery by controlling moisture absorption and dissolution rates for salicylic acid granules.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Shellac, a natural resin, is used in drug delivery.
  • Modifications of shellac may enhance its properties for pharmaceutical applications.

Purpose of the Study:

  • To synthesize shellac esters.
  • To evaluate shellac esters as an encapsulating material for sustained drug release formulations.

Main Methods:

  • Shellac esters were prepared by reacting shellac with glycerol.
  • Salicylic acid granules were encapsulated using shellac and shellac ester solutions.
  • Coated microcapsules were analyzed for moisture absorption, flow properties, and drug dissolution.

Main Results:

  • Drug release from coated granules was dependent on the acid value of the shellac esters.

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  • Shellac esters demonstrated favorable characteristics for microencapsulation.

    • Conclusions:

    • Shellac esters show potential as a superior encapsulating agent compared to shellac for developing sustained release formulations.
    • The acid value of shellac esters is a critical factor influencing drug release kinetics.