Related Experiment Video

Updated: Mar 21, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

939

Epidemiology of left ventricular hypertrophy in hypertension: implications for the clinic

Dana Cramariuc1, Eva Gerdts2

  • 1a Department of Heart Disease , Haukeland University Hospital , Bergen , Norway.

Expert Review of Cardiovascular Therapy
|May 10, 2016
PubMed

Insights

Left ventricular hypertrophy (LVH), a complication of hypertension, significantly elevates the risk of heart failure and sudden cardiac death. Understanding LVH is crucial for managing hypertensive heart disease.

Area of Science:

  • Cardiology
  • Hypertension Research

Background:

  • Left ventricular hypertrophy (LVH) is a significant complication of hypertension, indicative of hypertensive heart disease.
  • LVH markedly increases patient risk for severe cardiovascular events, including sudden cardiac death, stroke, myocardial infarction, and heart failure.

Purpose of the Study:

  • To provide a clinical update on left ventricular hypertrophy (LVH) in the context of hypertension.
  • To address the evolving epidemiology and clinical considerations of LVH.

Main Methods:

  • Review of recent advancements in diagnostic tools for LVH.
  • Analysis of demographic shifts in hypertensive populations.
  • Expert commentary on modifying factors in LVH and myocardial dysfunction.

Main Results:

  • Epidemiology of LVH has evolved due to new diagnostic technologies and changing demographics.
  • Individualized LVH presentation is influenced by comorbidities, risk factors, and molecular pathways.
  • Systolic and diastolic myocardial dysfunction are key aspects of LVH.

Conclusions:

  • LVH in hypertension requires ongoing clinical attention and updated management strategies.
  • The interplay of risk factors and molecular mechanisms is critical in LVH pathophysiology.
  • Early detection and understanding of LVH are vital for preventing cardiovascular events.
Abstract

Keywords:
Left ventricular hypertrophyarterial hypertensionechocardiographyhypertensive heart diseaseleft ventricular concentric geometryleft ventricular diastolic functionleft ventricular systolic functionmyocardial functionobesitysex

More Related Videos

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

5.1K
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

15.1K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.3K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
643
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
916
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.5K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
709
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.2K