Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

2.4K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.4K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.3K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.3K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K
Lineage Commitment01:21

Lineage Commitment

4.5K
Commitment is the  process whereby stem cells:
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Traumatic posterior mediastinal hematoma with left atrial compression: A case series of a rare, life-threatening entity.

The journal of trauma and acute care surgery·2026
Same author

A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential.

Cell reports·2025
Same author

Omacetaxine and azacitidine for untreated patients with myelodysplastic syndromes and excess blasts: a phase I/II clinical trial.

EClinicalMedicine·2025
Same author

siRNA Mediated Genetic Perturbation of Primary Human Leukemia Stem and Progenitor Cells.

bioRxiv : the preprint server for biology·2025
Same author

Acute myeloid leukaemia cells express high levels of androgen receptor but do not depend on androgen signaling for survival.

Leukemia·2025
Same author

Beyond the break: development and validation of a new classification system for acute traumatic rib fractures.

Trauma surgery & acute care open·2025
Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026
Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026
Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same journal

Buruli ulcer in Africa: between innovation and pragmatism.

Nature reviews. Disease primers·2026
Same journal

Author Correction: Atopic dermatitis.

Nature reviews. Disease primers·2026
See all related articles

Related Experiment Video

Updated: Mar 21, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.9K

Acute myeloid leukaemia.

Asim Khwaja1, Magnus Bjorkholm2, Rosemary E Gale1

  • 1Department of Haematology, University College London, UCL Cancer Institute, 72 Huntley Street, London WC1E 6DD, UK.

Nature Reviews. Disease Primers
|May 10, 2016
PubMed
Summary
This summary is machine-generated.

Acute myeloid leukaemia (AML) is a blood cancer involving immature white blood cells. Epigenetic mutations are common early events, driving disease progression and impacting treatment strategies.

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

900
Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

31.0K

Related Experiment Videos

Last Updated: Mar 21, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.9K
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

900
Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

31.0K

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Acute myeloid leukaemia (AML) is a clonal hematopoietic stem cell disorder.
  • Characterized by abnormal myeloid cell differentiation, leading to immature malignant cells and reduced normal blood cell production.
  • Predominantly affects older adults, presenting with rapid onset symptoms due to bone marrow failure.

Purpose of the Study:

  • To review the current understanding of AML pathophysiology, genomics, and treatment.
  • To highlight recent advances in therapeutic strategies and their potential impact.

Main Methods:

  • Review of genomic landscape, including common early epigenetic mutations.
  • Analysis of current treatment modalities, including dose escalation, supportive care, and stem cell transplantation.
  • Exploration of emerging targeted therapies and immunotherapeutic approaches.

Main Results:

  • Genomic landscape reveals frequent mutations in epigenetic regulators as early events.
  • Treatment improvements in younger patients attributed to dose escalation and supportive care.
  • Allogeneic stem cell transplantation used for high-risk patients.
  • Numerous novel agents targeting specific pathways and immunotherapy are under investigation.

Conclusions:

  • Despite advances, AML mortality remains high, particularly in older patients.
  • Improved understanding of AML pathophysiology fuels optimism for new therapeutic agents.
  • Personalized treatment strategies incorporating mutational analysis are becoming integral to AML subclassification and management.