CRIBRIFORM-MORULAR VARIANT OF THYROID CANCER - A RED FLAG FOR FAMILIAL ADENOMATOUS POLYPOSIS

Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome characterized by the development of colorectal adenomas which may be caused by mutations of the Adenomatosis polyposis colon gene. Patients with FAP are at risk for several additional intestinal malignancies including well-differentiated thyroid cancer, childhood hepatoblastoma, and central nervous system tumors. Cribriform-morular variant (CMV) is a rare subtype of papillary thyroid carcinoma (PTC) that is associated with FAP, and is also seen in patients without FAP. Patients could present with PTC before they show signs and symptoms of colorectal polyps.