Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

10
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
10
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

44
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
44
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

19
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
19
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

6.5K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
6.5K
Atypical Pneumonia01:14

Atypical Pneumonia

9
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
9
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

4.0K
The pathophysiology of pneumonia involves the following steps:
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is it justified to order an upfront cytomegalovirus immunohistochemical stain in patients with severe inflammatory bowel disease and ulceration?

Human pathology·2026
Same author

Clinical correlates of cerebellar injury in preterm infants with surgical necrotizing enterocolitis.

Journal of neonatal-perinatal medicine·2024
Same author

Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C.

Virology journal·2024
Same author

Diagnostic accuracy of prenatal ultrasound in coarctation of aorta: systematic review and individual participant data meta-analysis.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024
Same author

Clinical impact of analgesic-sedative agents and peri-operative clinical status on white matter brain injury in preterm infants following surgical NEC.

Journal of neonatal-perinatal medicine·2023
Same author

Effect of RMGI Roughness and Dentin Bonding Primer on Shear Bond Strength of Sandwich-type Restorations.

Operative dentistry·2023

Related Experiment Video

Updated: Mar 21, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.7K

A CLEAR CASE OF MRSA SEPSIS, OF AN UNEXPECTED ORIGIN.

A DeWitt1, C Patel1, R Kuapati1

  • 1Department of Internal Medicine, Baton Rouge General Medical Center, Baton Rouge, Louisiana.

The Journal of the Louisiana State Medical Society : Official Organ of the Louisiana State Medical Society
|May 10, 2016
PubMed
Summary
This summary is machine-generated.

This case study highlights a severe methicillin-resistant Staphylococcus aureus (MRSA) prostatitis complicated by sepsis. Effective vancomycin treatment was crucial for resolving bacteremia and achieving patient recovery.

More Related Videos

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.7K
Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
06:34

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Published on: July 11, 2016

21.0K

Related Experiment Videos

Last Updated: Mar 21, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.7K
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.7K
Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
06:34

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Published on: July 11, 2016

21.0K

Area of Science:

  • Infectious Diseases
  • Urology
  • Critical Care Medicine

Background:

  • A 56-year-old male with uncontrolled type 2 diabetes and benign prostatic hypertrophy presented with sepsis secondary to prostatitis.
  • Initial treatment with ciprofloxacin and Foley catheterization was insufficient, leading to persistent symptoms and bacteremia.

Purpose of the Study:

  • To describe a complex case of methicillin-resistant Staphylococcus aureus (MRSA) prostatitis with persistent bacteremia.
  • To illustrate the management and successful treatment of severe MRSA prostatitis and sepsis.

Main Methods:

  • Clinical case presentation detailing patient history, physical examination, laboratory findings, and imaging results.
  • Intravenous vancomycin therapy initiated for persistent gram-positive cocci bacteremia, identified as MRSA.
  • Transthoracic echocardiogram performed to rule out endocarditis.

Main Results:

  • Blood cultures initially showed persistent MRSA bacteremia for three days despite vancomycin therapy.
  • Achieved blood sterilization after adequate vancomycin dosing, though MRSA persisted in urine cultures.
  • Transthoracic echocardiogram ruled out infective endocarditis.

Conclusions:

  • MRSA prostatitis can lead to severe sepsis and persistent bacteremia requiring aggressive antibiotic management.
  • Vancomycin is effective in treating MRSA bacteremia, even in complicated cases of prostatitis.
  • Close monitoring and appropriate antibiotic selection are critical for successful outcomes in patients with MRSA prostatitis and sepsis.