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The ProTides Boom.

Youcef Mehellou1

  • 1School of Pharmacy, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, B15 2TT, UK. y.mehellou@bham.ac.uk.

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|May 10, 2016
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Summary
This summary is machine-generated.

ProTide technology effectively masks nucleoside groups for nucleotide therapeutics discovery. This approach has led to approved antiviral drugs and numerous candidates in clinical development.

Keywords:
nucleosidesnucleotidesphosphorylationprodrugsprotides

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Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Nucleotide Therapeutics

Background:

  • The ProTide technology involves masking nucleoside phosphate/phosphonate groups using aryl motifs and amino acid esters.
  • Invented in the early 1990s by Chris McGuigan, ProTide technology has significantly impacted nucleotide drug development.

Purpose of the Study:

  • To highlight the development and success of ProTide technology.
  • To showcase the application of ProTides in discovering nucleotide therapeutics.

Main Methods:

  • Review of ProTide technology's chemical strategy.
  • Discussion of ProTide candidates progressing through clinical trials.

Main Results:

  • ProTide technology has inspired two FDA-approved antiviral nucleotide drugs.
  • Multiple ProTide-based nucleotide therapeutics are currently in (pre)clinical development.

Conclusions:

  • ProTide technology is a valuable and validated platform for developing novel nucleotide therapeutics.
  • The continued clinical progression of ProTide candidates underscores the technology's therapeutic potential.