Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Circuits01:25

Neural Circuits

3.2K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.2K
Neuroplasticity01:01

Neuroplasticity

2.3K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.3K
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

4.2K
Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
4.2K
Decision Making01:20

Decision Making

1.2K
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
1.2K
Long-term Potentiation01:35

Long-term Potentiation

59.3K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
59.3K
Long-term Potentiation01:25

Long-term Potentiation

3.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Laminar Organization of a Decision Circuit in Orbitofrontal Cortex is Agnostic to the Variable Encoding Scheme.

bioRxiv : the preprint server for biology·2026
Same author

Study protocol for a pragmatic parallel-group randomised controlled trial to evaluate the effectiveness of coaching with an online intervention, compared with the online intervention alone, for families of children who have experienced developmental regression.

BMJ open·2026
Same author

Nalmefene Mitigates Opioid-Induced Nausea and Vomiting in Postoperative Analgesia but Not Resting Pain.

Pain research & management·2026
Same author

A coach-supported, digital parenting programme for parents of adolescents at risk of suicide: pilot trial of acceptability, feasibility, validity and short-term effects.

BJPsych open·2026
Same author

Development and performance evaluation of a recombinant antigen - based ELISA and immunochromatography test for HCMV IgG detection.

BMC infectious diseases·2026
Same author

Patch-to-slide fusion deep learning model for histological diagnosis of early pregnancy loss including hydatidiform mole.

NPJ digital medicine·2026

Related Experiment Video

Updated: Mar 21, 2026

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
07:42

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

Published on: August 2, 2018

14.5K

Neuronal remapping and circuit persistence in economic decisions.

Jue Xie1, Camillo Padoa-Schioppa1,2,3

  • 1Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri, USA.

Nature Neuroscience
|May 10, 2016
PubMed
Summary

Neurons in the orbitofrontal cortex (OFC) remap to represent different goods across contexts, demonstrating flexible economic decision-making. The neural circuit

More Related Videos

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.4K
Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

6.5K

Related Experiment Videos

Last Updated: Mar 21, 2026

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
07:42

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

Published on: August 2, 2018

14.5K
Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.4K
Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

6.5K

Area of Science:

  • Neuroscience
  • Decision Science
  • Behavioral Economics

Background:

  • The orbitofrontal cortex (OFC) is crucial for economic decision-making.
  • Neurons in the OFC represent goods and their values during choice.
  • Understanding how the OFC handles diverse goods across contexts is key.

Purpose of the Study:

  • To investigate the stability and flexibility of neural representations in the OFC during economic decisions.
  • To determine if neuronal representations of goods change with behavioral context.

Main Methods:

  • Electrophysiological recordings from rhesus monkey brains.
  • Analysis of neuronal activity during economic decision tasks in varying contexts.

Main Results:

  • Orbitofrontal cortex neurons encoding specific goods or values remap to new goods when the behavioral context shifts.
  • Despite neuronal remapping, the overall circuit organization and individual cell functions remain stable across contexts.
  • Neurons that supported a particular decision in one context continued to support the same decision in different contexts.

Conclusions:

  • The OFC exhibits a flexible yet stable neural architecture for economic decisions.
  • Neuronal remapping allows the OFC to represent a wide variety of goods within a consistent decision-making framework.