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Updated: Mar 21, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
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Lung cancer screening.

Lynn T Tanoue1

  • 1Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale Cancer Center Thoracic Oncology Program, Yale School of Medicine, New Haven, Connecticut, USA.

Current Opinion in Pulmonary Medicine
|May 10, 2016
PubMed
Summary
This summary is machine-generated.

Low-dose chest computed tomography screening reduces lung cancer mortality by 20% in high-risk individuals. Minimizing harms like false positives and ensuring informed decisions are crucial for effective lung cancer screening programs.

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MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

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Area of Science:

  • Pulmonology
  • Oncology
  • Radiology

Background:

  • Lung cancer screening with low-dose chest CT is recommended for high-risk individuals.
  • The National Lung Screening Trial showed a 20% relative reduction in lung cancer mortality.

Purpose of the Study:

  • To review the benefits and harms of lung cancer screening.
  • To discuss strategies for optimizing screening practices.

Main Methods:

  • Review of randomized controlled trials, including the National Lung Screening Trial.
  • Analysis of potential harms and benefits of screening.
  • Discussion of components for high-quality screening programs.

Main Results:

  • Low-dose chest CT screening significantly reduces lung cancer mortality.
  • Screening has a high false-positive rate, leading to further testing and potential harms.
  • Informed decision-making, individualized risk assessment, and tobacco treatment are essential.

Conclusions:

  • Lung cancer screening is beneficial but requires careful management of harms.
  • Multidisciplinary programs and ongoing research are needed to refine screening practices.
  • Novel biomarkers may improve the accuracy and effectiveness of future lung cancer screening.